Antibiotic-Resistant Escherichia coli and Class 1 Integrons in Humans, Domestic Animals, and Wild Primates in Rural Uganda-Reference-Cited by-同舟云学术

Antibiotic-Resistant Escherichia coli and Class 1 Integrons in Humans, Domestic Animals, and Wild Primates in Rural Uganda

Published:2018-11 Issue:21 Volume:84 Page:
ISSN:0099-2240
Container-title:Applied and Environmental Microbiology
language:en
Short-container-title:Appl Environ Microbiol

Author:

Weiss Debora¹²,Wallace Ryan M.³⁴,Rwego Innocent B.⁵⁶,Gillespie Thomas R.⁷,Chapman Colin A.⁸,Singer Randall S.⁶,Goldberg Tony L.⁴⁵^ORCID

Affiliation:

1. Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Georgia, USA

2. Wisconsin Department of Health Services, Division of Public Health, Bureau of Environmental and Occupational Health, Madison, Wisconsin, USA

3. Poxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA

4. Department of Pathobiological Sciences and Global Health Institute, University of Wisconsin-Madison, Madison, Wisconsin, USA

5. Department of Biosecurity, Ecosystems and Veterinary Public Health, Makerere University, Kampala, Uganda

6. Department of Veterinary Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota, USA

7. Department of Environmental Sciences and Program in Population Biology, Ecology and Evolution, Emory University, Atlanta, Georgia, USA

8. Department of Anthropology, McGill University, Montreal, Quebec, Canada

Abstract

Antibiotic resistance is a global problem. This study, conducted in rural western Uganda, describes antibiotic resistance patterns in Escherichia coli bacteria near two forested national parks. Resistance was present not only in people, but also in their livestock and in nearby wild nonhuman primates. Multidrug resistance and class 1 integrons containing genes that confer resistance were common and were similar in people and animals. The percentage of resistant isolates decreased with increasing local price of the antibiotic. Antibiotic resistance in this setting likely reflects environmental diffusion of bacteria or their genes, perhaps facilitated by local ecological and socioeconomic conditions.

Funder

Morris Animal Foundation

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

Link

https://journals.asm.org/doi/pdf/10.1128/AEM.01632-18

Reference44 articles.

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