Single-Cell RNA Sequencing Reveals the Heterogeneity of Infiltrating Immune Cell Profiles in the Hepatic Cystic Echinococcosis Microenvironment-Reference-Cited by-同舟云学术

Single-Cell RNA Sequencing Reveals the Heterogeneity of Infiltrating Immune Cell Profiles in the Hepatic Cystic Echinococcosis Microenvironment

Published:2021-11-16 Issue:12 Volume:89 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Yasen Aimaiti¹,Sun Wujianan²,Aini Abudusalamu¹^ORCID,Aji Tuerganaili³,Shao Yingmei³,Wang Hui⁴,Li Kun²,Li Wending¹,Zhang Chuanshan⁴,Ahan Ayifuhan³,Jiang Tiemin³,Wang Zongding¹,Zhang Wenbao¹,Sun Cheng⁵,Qu Kun²⁵,Wen Hao¹³^ORCID

Affiliation:

1. State Key Laboratory of Pathogenesis, Prevention and Management of High Incidence Diseases in Central Asia, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China

2. Department of Oncology, The First Affiliated Hospital of USTC, Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China

3. Department of Hepatobiliary and Echinococcosis Surgery, Digestive and Vascular Surgery Center, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China

4. Xinjiang Uyghur Autonomous Region Key Laboratory of Echinococcosis, Clinical Medical Institute, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China

5. School of Data Science, University of Science and Technology of China, Hefei, China

Abstract

Human cystic echinococcosis, caused by the larval stage of Echinococcus granulosus sensu lato , has been reported a near-cosmopolitan zoonotic disease. Various infiltrating immune cells gather around the lesion and produce a lesion microenvironment; however, cellular composition and heterogeneity in hepatic cystic echinococcosis lesion microenvironments are incompletely understood.

Funder

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00297-21

Reference58 articles.

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3. Global Socioeconomic Impact of Cystic Echinococcosis