Generation and Characterization of Typhoid Toxin-Neutralizing Human Monoclonal Antibodies-Reference-Cited by-同舟云学术

Generation and Characterization of Typhoid Toxin-Neutralizing Human Monoclonal Antibodies

Published:2020-09-18 Issue:10 Volume:88 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Jiao Xuyao¹,Smith Sarah²,Stack Gabrielle¹,Liang Qi²,Bradley Allan²,Kellam Paul²,Galán Jorge E.¹^ORCID

Affiliation:

1. Department of Microbial Pathogenesis, Yale School of Medicine, New Haven, Connecticut, USA

2. Kymab Ltd., Babraham Research Campus, Cambridge, United Kingdom

Abstract

Typhoid toxin is a virulence factor of Salmonella enterica serovar Typhi, the causative agent of typhoid fever, and is thought to be responsible for the symptoms of severe disease. This toxin has a unique A2B5 architecture with two active subunits, the ADP ribosyl transferase PltA and the DNase CdtB, linked to a pentameric B subunit, which is alternatively made of PltB or PltC. Here, we describe the generation and characterization of typhoid toxin-neutralizing human monoclonal antibodies by immunizing genetically engineered mice that have a full set of human immunoglobulin variable region genes.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Bill and Melinda Gates Foundation

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00292-20

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