Phage Lysin LysK Can Be Truncated to Its CHAP Domain and Retain Lytic Activity against Live Antibiotic-Resistant Staphylococci-Reference-Cited by-同舟云学术

Phage Lysin LysK Can Be Truncated to Its CHAP Domain and Retain Lytic Activity against Live Antibiotic-Resistant Staphylococci

Published:2009-02 Issue:3 Volume:75 Page:872-874
ISSN:0099-2240
Container-title:Applied and Environmental Microbiology
language:en
Short-container-title:Appl Environ Microbiol

Author:

Horgan Marianne¹²,O’Flynn Gary¹²,Garry Jennifer¹³,Cooney Jakki⁴,Coffey Aidan³,Fitzgerald Gerald F.²⁵,Ross R. Paul¹⁵,McAuliffe Olivia¹

Affiliation:

1. Teagasc, Moorepark Food Research Centre, Fermoy, County Cork, Ireland

2. Department of Microbiology, University College Cork, Cork, Ireland

3. Department of Biological Sciences, Cork Institute of Technology, Cork, Ireland

4. Department of Life Sciences, Materials and Surface Science Institute, University of Limerick, Limerick, Ireland

5. Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland

Abstract

ABSTRACT A truncated derivative of the phage endolysin LysK containing only the CHAP (cysteine- and histidine-dependent amidohydrolase/peptidase) domain exhibited lytic activity against live clinical staphylococcal isolates, including methicillin-resistant Staphylococcus aureus . This is the first known report of a truncated phage lysin which retains high lytic activity against live staphylococcal cells.

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

Link

https://journals.asm.org/doi/pdf/10.1128/AEM.01831-08

Reference30 articles.

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