Functional Impairment of Simian Immunodeficiency Virus-Specific CD8 + T Cells during the Chronic Phase of Infection-Reference-Cited by-同舟云学术

Functional Impairment of Simian Immunodeficiency Virus-Specific CD8 + T Cells during the Chronic Phase of Infection

Published:2001-03 Issue:5 Volume:75 Page:2458-2461
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Vogel Thorsten U.¹,Allen Todd M.¹,Altman John D.²,Watkins David I.¹³

Affiliation:

1. Wisconsin Regional Primate Research Center1 and

2. Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia 303222

3. Department of Pathology and Laboratory Medicine,3 University of Wisconsin, Madison, Wisconsin 53715, and

Abstract

ABSTRACT In an attempt to determine why high frequencies of circulating virus-specific CD8 + T cells are unable to control human immunodeficiency virus and simian immunodeficiency virus (SIV) replication, we assessed the functional nature of SIV-specific CD8 + lymphocytes. After vaccination and early after infection, nearly all tetramer-staining CD8 + cells produced gamma interferon in response to their specific stimulus. However, by 4 months postinfection with pathogenic SIVmac239, signs of functional impairment in the CD8 + T-cell compartment were detected which might prevent these T cells from efficiently controlling the infection during the chronic phase.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.75.5.2458-2461.2001

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