New SHIVs and Improved Design Strategy for Modeling HIV-1 Transmission, Immunopathogenesis, Prevention, and Cure-Reference-Cited by-同舟云学术

New SHIVs and Improved Design Strategy for Modeling HIV-1 Transmission, Immunopathogenesis, Prevention, and Cure

Published:2021-05-10 Issue:11 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Li Hui¹²,Wang Shuyi¹²,Lee Fang-Hua¹²,Roark Ryan S.¹²,Murphy Alex I.¹²,Smith Jessica¹²,Zhao Chengyan¹²,Rando Juliette¹²,Chohan Neha¹²,Ding Yu¹²,Kim Eunlim¹²,Lindemuth Emily¹²,Bar Katharine J.¹²,Pandrea Ivona³,Apetrei Cristian⁴^ORCID,Keele Brandon F.⁵^ORCID,Lifson Jeffrey D.⁵,Lewis Mark G.⁶,Denny Thomas N.⁷⁸,Haynes Barton F.⁷⁸,Hahn Beatrice H.¹²,Shaw George M.¹²^ORCID

Affiliation:

1. Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

2. Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

3. Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

4. Division of Infectious Diseases, Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

5. AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA

6. Bioqual, Inc., Rockville, Maryland, USA

7. Duke Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina, USA

8. Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA

Abstract

SHIV infection of Indian rhesus macaques is an important animal model for studying HIV-1 transmission, prevention, immunopathogenesis, and cure. Such research is timely, given recent progress with active and passive immunization and novel approaches to HIV-1 cure.

Funder

Bill and Melinda Gates Foundation

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00071-21

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