Latent herpes simplex virus type 1 gene expression in ganglia innervating the human gastrointestinal tract

Author:

Gesser R M1,Koo S C1

Affiliation:

1. Division of Allergy, Immunology and Infectious Diseases, The Children's Hospital of Philadelphia, Pennsylvania 19104, USA. gesser@email.chop.edu

Abstract

Using in situ hybridization, we demonstrated that latent herpes simplex virus type 1 (HSV-1) gene expression is prevalent in human adult nodose ganglia. This suggests that infection of gastrointestinal sensory nerves, probably through swallowed virus-laden oral secretions, occurs commonly and that HSV-1 reactivating from this site may play a role in recurrent gastrointestinal disorders.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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4. Herpesvirus hominis: isolation from human trigeminal ganglion;Bastian F. O.;Science,1972

5. Studies of the natural history of herpes simplex virus infections;Buddingh G. J.;Pediatrics,1953

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