Comparative Genomics of Serial Candida glabrata Isolates and the Rapid Acquisition of Echinocandin Resistance during Therapy

Author:

Barber Amelia E.1,Weber Michael123,Kaerger Kerstin1,Linde Jörg23,Gölz Hanna4,Duerschmied Daniel56,Markert Antonie6,Guthke Reinhard2,Walther Grit1,Kurzai Oliver17ORCID

Affiliation:

1. National Reference Center for Invasive Mycoses, Leibniz Institute for Natural Product Research and Infection Biology–Hans Knoell Institute, Jena, Germany

2. Systems Biology and Bioinformatics, Leibniz Institute for Natural Product Research and Infection Biology–Hans Knoell Institute, Jena, Germany

3. Research Group PiDOMICs, Leibniz Institute for Natural Product Research and Infection Biology–Hans Knoell Institute, Jena, Germany

4. Institute of Medical Microbiology and Hygiene, Faculty of Medicine, Medical Center-University of Freiburg, Freiburg, Germany

5. Department of Cardiology and Angiology I, Heart Center, University of Freiburg, Freiburg, Germany

6. Department of Medicine III: Medical Intensive Care, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany

7. Institute for Hygiene and Microbiology, Julius Maximilian University of Wuerzburg, Wuerzburg, Germany

Abstract

The opportunistic pathogen Candida glabrata shows a concerning increase in drug resistance. Here, we present the analysis of two serial bloodstream isolates, obtained 12 days apart.

Funder

Robert Koch Institute

Free State of Thuringia

Deutsche Forschungsgemeinschaft

Bundesministerium für Bildung und Forschung

EC | European Regional Development Fund

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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