Molecular Characterization of β-Lactamase Genes and Their Genetic Structures in Acinetobacter Genospecies 3 Isolates in Taiwan-Reference-Cited by-同舟云学术

Molecular Characterization of β-Lactamase Genes and Their Genetic Structures in Acinetobacter Genospecies 3 Isolates in Taiwan

Published:2010-06 Issue:6 Volume:54 Page:2699-2703
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Huang Li-Yueh¹,Lu Po-Liang²³,Chen Te-Li⁴⁵,Chang Fang-Yee¹⁶,Fung Chang-Phone⁴,Siu L. K.¹⁶⁷

Affiliation:

1. Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei

2. Department of Internal Medicine and Laboratory Medicine, Kaohsiung Medical University Hospital, Kaohsiung

3. School of Medicine, Kaohsiung Medical University, Kaohsiung

4. Section of Infectious Diseases, Department of Medicine, Taipei Veterans General Hospital, Taipei

5. Institute of Clinical Medicine, School of Medicine, National Yang-Ming University, Taipei

6. Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Tri-Service General Hospital, Taipei

7. Division of Infectious Diseases, National Health Research Institutes, Zhunan Town, Miaoli County, Taiwan

Abstract

ABSTRACT The genetic structure of β-lactamases in Acinetobacter genospecies 3 (AG3) isolates in Taiwan was studied to analyze their high rates of resistance to β-lactams, including carbapenems (57.9%). bla IMP-1 and bla IMP-8 were located in a class 1 integron. bla OXA-58 was bracketed by IS Aba3 . A novel TnpF-like integrase gene was identified upstream of bla VEB-3 . Adjacent to the 5′ sequence of the bla ADC gene, folE was identified. Four new Acinetobacter -derived cephalosporinase (ADC) enzymes were found, which clustered phylogenetically with published AG3 ADC proteins.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01624-09

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