Nukacin ISK-1, a Bacteriostatic Lantibiotic-Reference-Cited by-同舟云学术

Nukacin ISK-1, a Bacteriostatic Lantibiotic

Published:2009-08 Issue:8 Volume:53 Page:3595-3598
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Asaduzzaman Sikder M.¹,Nagao Jun-ichi²,Iida Hiroshi³,Zendo Takeshi¹,Nakayama Jiro¹,Sonomoto Kenji¹⁴

Affiliation:

1. Laboratory of Microbial Technology, Division of Microbial Science and Technology, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan

2. Section of Infection Biology, Department of Functional Bioscience, Fukuoka Dental College, 2-15-1 Tamura, Sawara-ku, Fukuoka 814-0193, Japan

3. Department of Applied Genetic and Pest Management, Faculty of Agriculture, Graduate School, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan

4. Laboratory of Functional Food Design, Department of Functional Metabolic Design, Bio-Architecture Center, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan

Abstract

ABSTRACT We determined the mode of action of nukacin ISK-1. It did not cause membrane potential dissipation or the efflux of ATP or K + ions from the cells of a sensitive bacterial strain; however, it blocked the membrane depolarization activity of nisin. Nukacin ISK-1-treated cells had single arrangements of cells without the formation of a complete septum. A remarkable reduction in cell wall width was also observed, but cytoplasmic content was unaffected. We concluded that nukacin ISK-1 is bacteriostatic.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01623-08

Reference14 articles.

1. Lysine-Oriented Charges Trigger the Membrane Binding and Activity of Nukacin ISK-1

2. Aso, Y., K. Okuda, J. Nagao, Y. Kamenasa, N. T. B. Phuong, H. Koga, K. Shioya, T. Sashihara, J. Nakayama, and K. Sonomoto. 2005. A novel type of immunity protein, NukH, for the lantibiotic nukacin ISK-1 produced by Staphylococcus warneri ISK-1. Biosci. Biotechnol. Biochem.69:1403-1410.

3. Lipid II Is an Intrinsic Component of the Pore Induced by Nisin in Bacterial Membranes

4. Use of the Cell Wall Precursor Lipid II by a Pore-Forming Peptide Antibiotic

5. Mode of action of the lantibiotic mersacidin: inhibition of peptidoglycan biosynthesis via a novel mechanism?

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