Lack of the Major Multifunctional Catalase KatA in Pseudomonas aeruginosa Accelerates Evolution of Antibiotic Resistance in Ciprofloxacin-Treated Biofilms-Reference-Cited by-同舟云学术

Lack of the Major Multifunctional Catalase KatA in Pseudomonas aeruginosa Accelerates Evolution of Antibiotic Resistance in Ciprofloxacin-Treated Biofilms

Published:2019-10 Issue:10 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Ahmed Marwa N.¹²,Porse Andreas³,Abdelsamad Ahmed⁴⁵,Sommer Morten³,Høiby Niels¹⁶,Ciofu Oana¹

Affiliation:

1. Costerton Biofilm Center, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark

2. Department of Microbiology, Faculty of Agriculture, Cairo University, Giza, Egypt

3. Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Lyngby, Denmark

4. Department of Genetics, Faculty of Agriculture, Cairo University, Giza, Egypt

5. Department of Biology, University of Copenhagen, Copenhagen, Denmark

6. Department of Clinical Microbiology, Rigshospitalet, Copenhagen, Denmark

Abstract

During chronic biofilm infections, Pseudomonas aeruginosa bacteria are exposed to increased oxidative stress as a result of the inflammatory response. As reactive oxygen species (ROS) are mutagenic, the evolution of resistance to ciprofloxacin (CIP) in biofilms under oxidative stress conditions was investigated.

Funder

European Union H2020

The Egyptian Ministry of Higher Education

Novo Nordisk UK Research Foundation

Det Frie Forskningsråd

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00766-19

Reference42 articles.