Emergence and Plasmid Analysis of Klebsiella pneumoniae KP01 CarryingblaGES-5from Guangzhou, China

Abstract

ABSTRACTKlebsiella pneumoniaestrain KP01 carryingblaGES-5was identified from a patient in Guangzhou, China. High-throughput sequencing assignedblaGES-5to a 28.5-kb nonconjugative plasmid, pGES-GZ. A 13-kb plasmid backbone sequence on pGES-GZ was found to share high sequence identities with plasmids from Gram-negative nonfermenters. A novel class 1 integron carrying a gene cassette array oforf28-orf28-blaGES-5was identified on pGES-GZ, within whichorf28encoded a hypothetical protein possibly correlated to fosfomycin resistance.