The Simple One-Step (SOS) Stool Processing Method for Use with the Xpert MTB/RIF Assay for a Child-Friendly Diagnosis of Tuberculosis Closer to the Point of Care

Author:

de Haas Petra1ORCID,Yenew Bazezew2,Mengesha Endale3,Slyzkyi Andrii1,Gashu Zewdu3,Lounnas Manon4,Tesfaye Ephrem2,Bedru Ahmed3,Tiemersma Edine1ORCID,Kremer Kristin1,Amare Misikir2,Diriba Getu2,Zerihun Betselot2,Gudina Tilaye5,Tegegn Ben6,Bonnet Maryline7,Negeri Challa3,Klinkenberg Eveline18ORCID

Affiliation:

1. KNCV Tuberculosis Foundation, The Hague, The Netherlands

2. Ethiopian Public Health Institute, Addis Ababa, Ethiopia

3. KNCV Tuberculosis Foundation Ethiopia Office, Addis Ababa, Ethiopia

4. UMR MIVEGEC IRD-CNRS-University of Montpellier, IRD, Montpellier, France

5. National Tuberculosis and Leprosy Control Program, Addis Ababa, Ethiopia

6. Addis Ababa Regional Health Bureau, Addis Ababa, Ethiopia

7. IRD UMI 233 Trans-VIHMI-UM-INSERM U1175, Montpellier, France

8. Department of Global Health and Amsterdam Institute for Global Health and Development, Amsterdam University Medical Center, Amsterdam, The Netherlands

Abstract

Young children cannot easily produce sputum for diagnosis of pulmonary tuberculosis (TB). Alternatively, Mycobacterium tuberculosis complex bacilli can be detected in stool by using the Xpert MTB/RIF (Ultra) assay (Xpert).

Funder

Unitaid

United States Agency for International Development

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Reference27 articles.

1. Paediatric tuberculosis

2. Pediatric Tuberculosis: Global Overview and Challenges

3. World Health Organization. 2018. Roadmap towards ending TB in children and adolescents, 2nd ed. World Health Organization, Geneva, Switzerland. http://apps.who.int/iris/bitstream/handle/10665/275422/9789241514798-eng.pdf?ua=1.

4. Diagnostic practices and estimated burden of tuberculosis among children admitted to 13 government hospitals in Kenya: An analysis of two years’ routine clinical data

5. World Health Organization. 2020. WHO operational handbook on tuberculosis. Module 3: diagnosis: rapid diagnostics for tuberculosis detection. World Health Organization, Geneva, Switzerland. https://apps.who.int/iris/bitstream/handle/10665/332864/9789240007284-eng.pdf?sequence=1&isAllowed=y.

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