Chromosomally Encoded mcr-5 in Colistin-Nonsusceptible Pseudomonas aeruginosa-Reference-Cited by-同舟云学术

Chromosomally Encoded mcr-5 in Colistin-Nonsusceptible Pseudomonas aeruginosa

Published:2018-08 Issue:8 Volume:62 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Snesrud Erik¹,Maybank Rosslyn¹,Kwak Yoon I.¹,Jones Anthony R.¹,Hinkle Mary K.¹,McGann Patrick¹^ORCID

Affiliation:

1. Multi-drug Resistant Organism Repository and Surveillance Network, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA

Abstract

ABSTRACT Whole-genome sequencing (WGS) of historical Pseudomonas aeruginosa clinical isolates identified a chromosomal copy of mcr-5 within a Tn 3 -like transposon in P. aeruginosa MRSN 12280. The isolate was nonsusceptible to colistin by broth microdilution, and genome analysis revealed no mutations known to confer colistin resistance. To the best of our knowledge, this is the first report of mcr in colistin-nonsusceptible P. aeruginosa .

Funder

Global Emerging Infections Surveillance

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00679-18

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