Role of Whole-Genome Sequencing in Characterizing the Mechanism of Action of para -Aminosalicylic Acid and Its Resistance-Reference-Cited by-同舟云学术

Role of Whole-Genome Sequencing in Characterizing the Mechanism of Action of para -Aminosalicylic Acid and Its Resistance

Published:2020-08-20 Issue:9 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Satta Giovanni¹²^ORCID,Witney Adam A.³,Begum Neelu¹,Ortiz Canseco Julio¹,Boa Andrew N.⁴,McHugh Timothy D.¹

Affiliation:

1. Centre for Clinical Microbiology, University College London, London, United Kingdom

2. Department of Infectious Disease, Imperial College London, London, United Kingdom

3. Institute for Infection and Immunity, St. George’s University of London, London, United Kingdom

4. Department of Chemistry, University of Hull, Hull, United Kingdom

Abstract

para -Aminosalicylic acid (PAS) remains one of the drugs of last resort for the treatment of tuberculosis, but its mechanism of action is still not completely understood. The main aim of this project was to identify new potential mechanisms of action and resistance to PAS by performing whole-genome sequencing on PAS-resistant laboratory mutants. A new variant in the folC gene was identified, as well as some other mutations that require further study.

Funder

University College London

UoL | St. George's, University of London

University of Hull

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00675-20

Reference16 articles.

1. Para-aminosalicylic acid: the return of an old friend