Efficacy of Ambruticin Analogs in a Murine Model of Coccidioidomycosis-Reference-Cited by-同舟云学术

Efficacy of Ambruticin Analogs in a Murine Model of Coccidioidomycosis

Published:2006-10 Issue:10 Volume:50 Page:3467-3469
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Shubitz Lisa F.¹²,Galgiani John N.³²⁴,Tian Zong-Qiang⁵,Zhong Ziyang⁵,Timmermans Pieter⁵,Katz Leonard⁵

Affiliation:

1. Department of Veterinary Science and Microbiology

2. Valley Fever Center for Excellence

3. Department of Medicine, University of Arizona

4. Southern Arizona Veterans Health Care Administration, Tucson, Arizona

5. Kosan Biosciences, Inc., Hayward, California

Abstract

ABSTRACT Ambruticin S, an antifungal cyclopropyl-pyran acid, showed curative effects against murine coccidioidal infection. Two analogs of this compound with greater in vitro potency were tested against lethal murine Coccidioides infection. Both improved the survival of mice over that of controls; one resulted in near-sterilization of infection.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00670-06

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