Piperidine-4-Carboxamides Target DNA Gyrase in Mycobacterium abscessus-Reference-Cited by-同舟云学术

Piperidine-4-Carboxamides Target DNA Gyrase in Mycobacterium abscessus

Published:2021-07-16 Issue:8 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Negatu Dereje Abate¹²,Beuchel Andreas³,Madani Abdeldjalil¹,Alvarez Nadine¹,Chen Chao¹,Aragaw Wassihun Wedajo¹,Zimmerman Matthew D.¹,Laleu Benoît⁴,Gengenbacher Martin¹⁵^ORCID,Dartois Véronique¹⁵^ORCID,Imming Peter³,Dick Thomas¹⁵⁶^ORCID

Affiliation:

1. Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA

2. Center for Innovative Drug Development and Therapeutic Trials for Africa (CDT-Africa), Addis Ababa University, Addis Ababa, Ethiopia

3. Institut für Pharmazie, Martin-Luther-Universität Halle-Wittenberg, Halle, Germany

4. Medicines for Malaria Venture, Geneva, Switzerland

5. Department of Medical Sciences, Hackensack Meridian School of Medicine, Nutley, New Jersey, USA

6. Department of Microbiology and Immunology, Georgetown University, Washington, DC, USA

Abstract

New, more-effective drugs for the treatment of lung disease caused by nontuberculous mycobacteria (NTM) are needed. Among NTM opportunistic pathogens, Mycobacterium abscessus is the most difficult to cure and intrinsically multidrug resistant. In a whole-cell screen of a compound collection active against Mycobacterium tuberculosis , we previously identified the piperidine-4-carboxamide (P4C) MMV688844 (844) as a hit against M. abscessus .

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00676-21

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