Killing of Plasmodium falciparum in vitro by nitric oxide derivatives-Reference-Cited by-同舟云学术

Killing of Plasmodium falciparum in vitro by nitric oxide derivatives

Published:1991-09 Issue:9 Volume:59 Page:3280-3283
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Rockett K A¹,Awburn M M¹,Cowden W B¹,Clark I A¹

Affiliation:

1. Division of Cell Biology, John Curtin School of Medical Research, Canberra, A.C.T., Australia.

Abstract

We have investigated the in vitro susceptibility of the human malaria parasite Plasmodium falciparum to killing by nitric oxide and related molecules. A saturated solution of nitric oxide did not inhibit parasite growth, but two oxidation products of nitric oxide (nitrite and nitrate ions) were toxic to the parasite in millimolar concentrations. Nitrosothiol derivatives of cysteine and glutathione were found to be about a thousand times more active (50% growth inhibitory concentration, approximately 40 microM) than nitrite.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.59.9.3280-3283.1991

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