Structure of Rift Valley Fever Virus RNA-Dependent RNA Polymerase-Reference-Cited by-同舟云学术

Structure of Rift Valley Fever Virus RNA-Dependent RNA Polymerase

Published:2022-02-09 Issue:3 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Wang Xue¹,Hu Cuixia²,Ye Wei³,Wang Jia²,Dong Xiaofei¹,Xu Jie²,Li Xiaorong¹,Zhang Manfeng¹,Lu Hongyun¹,Zhang Fanglin³,Wu Wei¹,Dai Shaodong⁴,Wang Hong-Wei²,Chen Zhongzhou¹^ORCID

Affiliation:

1. State Key Laboratory of Agrobiotechnology and Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Biological Sciences, China Agricultural University, Beijing, China

2. Ministry of Education Key Laboratory of Protein Science, Tsinghua-Peking Joint Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing, China

3. Department of Microbiology, School of Preclinical Medicine, Fourth Military Medical University, Xi’an, China

4. Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA

Abstract

The zoonosis RVF virus (RVFV) is one of the most serious arbovirus threats to both human and animal health. RNA-dependent RNA polymerase (RdRp) is a multifunctional enzyme catalyzing genome replication as well as viral transcription, so the RdRp is essential for studying the virus and has multiple drug targets.

Funder

MOST | National Key Research and Development Program of China

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.01713-21

Reference62 articles.

1. Three-Dimensional Organization of Rift Valley Fever Virus Revealed by Cryoelectron Tomography

2. Asymmetric Trimeric Ring Structure of the Nucleocapsid Protein of Tospovirus