A Repetitive Region of Gammaherpesvirus Genomic DNA Is a Ligand for Induction of Type I Interferon-Reference-Cited by-同舟云学术

A Repetitive Region of Gammaherpesvirus Genomic DNA Is a Ligand for Induction of Type I Interferon

Published:2008-03 Issue:5 Volume:82 Page:2208-2217
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Sanchez David Jesse¹,Miranda Daniel¹,Arumugaswami Vaithilingaraja²,Hwang Seungmin²,Singer Adam E.³,Senaati Ashkon¹,Shahangian Arash¹⁴,Song Moon Jung⁵,Sun Ren²⁶⁷,Cheng Genhong¹⁶

Affiliation:

1. Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, California

2. Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, California

3. Department of Molecular & Cell Biology, University of California, Berkeley, Berkeley, California

4. MSTP Graduate Program, University of California, Los Angeles, Los Angeles, California

5. Division of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, South Korea

6. Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, California

7. UCLA AIDS Institute, University of California, Los Angeles, Los Angeles, California

Abstract

ABSTRACT Innate immune responses against viral infection, especially the induction of type I interferon, are critical for limiting the replication of the virus. Although it has been shown that DNA can induce type I interferon, to date no natural DNA ligand of a virus that induces type I interferon has been described. Here we screened the genome of murine gammaherpesvirus 68 with mutations at various genomic locations to map the region of DNA that induces type I interferon. A repetitive region termed the 100-base-pair repeat region is a ligand that is both necessary and sufficient for the viral genomic DNA to induce type I interferon. A region colinear with this ligand in the genome of Kaposi's sarcoma-associated herpesvirus also induces type I interferon. We have thus defined a repetitive region of the genomes of gammaherpesviruses as the first natural DNA virus ligand that induces type I interferon.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01718-07

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