Influenza A Virus Agnostic Receptor Tropism Revealed Using a Novel Biological System with Terminal Sialic Acid Knockout Cells

Author:

Kamiki Haruhiko1,Murakami Shin1ORCID,Nishikaze Takashi2,Hiono Takahiro3,Igarashi Manabu4,Furuse Yuki5,Matsugo Hiromichi1,Ishida Hiroho1,Katayama Misa1,Sekine Wataru1,Muraki Yasushi6ORCID,Takahashi Masateru7,Takenaka-Uema Akiko1,Horimoto Taisuke1ORCID

Affiliation:

1. Laboratory of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan

2. Koichi Tanaka Mass Spectrometry Research Laboratory, Shimadzu Corporation, Nishinokyo-Kuwabaracho, Kyoto, Japan

3. Molecular and Cellular Glycoproteomics Research Group, Cellular and Molecular Biotechnology Research Institute, National Institute of Advanced Industrial Science & Technology, Tsukuba, Japan

4. Division of Global Epidemiology, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan

5. Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan

6. Iwate Medical University, Morioka, Japan

7. Research Institute for Environmental Sciences and Public Health of Iwate Prefecture, Morioka, Japan

Abstract

The acquisition of mutations that allow avian influenza A virus hemagglutinins to recognize human-type receptors is mandatory for the transmission of avian viruses to humans, which could lead to a pandemic. In this study, we established a novel system using a set of genetically engineered MDCK cells with knocked out sialic acid receptors to biologically evaluate the receptor tropism for influenza A viruses.

Funder

MEXT | Japan Society for the Promotion of Science

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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