Influence of NKG2C Genotypes on HIV Susceptibility and Viral Load Set Point-Reference-Cited by-同舟云学术

Influence of NKG2C Genotypes on HIV Susceptibility and Viral Load Set Point

Published:2021-07-26 Issue:16 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Alsulami Khlood¹²³,Bolastig Naomi¹³,Dupuy Franck P.¹³,Mabanga Tsoarello¹³,Gilbert Louise¹³,Kiani Zahra¹³,Routy Jean-Pierre¹²³⁴⁵,Bruneau Julie⁶⁷,Thomas Réjean⁸,Tremblay Cécile⁶⁹,Tsoukas Christos M.¹²³¹⁰,Szabo Jason³⁷⁸,Côté Pierre¹¹,Trottier Benoit¹¹,LeBlanc Roger¹²,Rouleau Danielle⁹,Bernard Nicole F.¹²³⁵¹⁰^ORCID

Affiliation:

1. Research Institute of the McGill University Health Centre (RI-MUHC), Montreal, Quebec, Canada

2. Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada

3. Infectious Diseases, Immunology and Global Health Program, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada

4. Division of Hematology, McGill University Health Centre, Montreal, Quebec, Canada

5. Chronic Viral Illness Service, McGill University Health Centre, Montreal, Quebec, Canada

6. Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, Quebec, Canada

7. Department of Family Medicine, Université de Montréal, Montreal, Quebec, Canada

8. Clinique Médicale l'Actuel, Montréal, Quebec, Canada

9. Department of Microbiology, Infectiology, and Immunology, University of Montreal, Montreal, Quebec, Canada

10. Division of Clinical Immunology, McGill University Health Centre, Montreal, Quebec, Canada

11. Clinique de Médecine Urbaine du Quartier Latin, Montréal, Quebec, Canada

12. Clinique Médicale Opus, Montréal, Quebec, Canada

Abstract

We compared NKG2C allele and genotype distributions in subjects who remained HIV uninfected despite multiple HIV exposures (HESN subjects) with those in the group PLWH. This allowed us to determine whether NKG2C genotype influenced susceptibility to HIV infection.

Funder

Fonds de Recherche du Québec - Santé

Gouvernement du Canada | Canadian Institutes of Health Research

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00417-21

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2. Up on the tightrope: natural killer cell activation and inhibition