Pharmacokinetics of Intraperitoneal and Intravenous Fosfomycin in Automated Peritoneal Dialysis Patients without Peritonitis-Reference-Cited by-同舟云学术

Pharmacokinetics of Intraperitoneal and Intravenous Fosfomycin in Automated Peritoneal Dialysis Patients without Peritonitis

Published:2012-07 Issue:7 Volume:56 Page:3992-3995
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Tobudic Selma¹,Matzneller Peter²,Stoiser Brigitte¹,Wenisch Judith Maria¹,Zeitlinger Markus²,Vychytil Andreas³,Jaeger Walter⁴,Boehmdorfer Michaela⁴,Reznicek Gottfried⁴,Burgmann Heinz¹

Affiliation:

1. Department of Internal Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University of Vienna, Vienna, Austria

2. Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria

3. Department of Internal Medicine III, Division of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria

4. Department of Pharmacology and Toxicology, University of Vienna, Vienna, Austria

Abstract

ABSTRACT Blood and dialysate concentrations of fosfomycin were determined after intravenous and intraperitoneal application of 4 mg/liter in patients undergoing automated peritoneal dialysis. Maximum serum concentrations after intravenous (287.75 ± 86.34 mg/liter) and intraperitoneal (205.78 ± 66.78 mg/liter) administration were comparable. Ratios of intraperitoneal to systemic exposure were 1.12 (intraperitoneal administration) and 0.22 (intravenous administration), indicating good systemic exposure after intraperitoneal application but limited penetration of fosfomycin into the peritoneal fluid after the intravenous dose.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00126-12

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