Comparing QuantiFERON-TB Gold Plus with Other Tests To Diagnose Mycobacterium tuberculosis Infection

Author:

Venkatappa Thara K.1,Punnoose Rose2,Katz Dolly J.1,Higgins Michael P.3,Banaei Niaz4,Graviss Edward A.5,Belknap Robert W.3,Ho Christine S.1

Affiliation:

1. Division of Tuberculosis Elimination, Centers for Disease Control and Prevention, Atlanta, Georgia, USA

2. Northrop Grumman, Atlanta, Georgia, USA

3. Denver Health and Hospital Authority, Denver, Colorado, USA

4. Department of Pathology, Stanford University School of Medicine, Stanford, California, USA

5. Department of Pathology and Genomic Medicine, Houston Methodist Research Institute, Houston, Texas, USA

Abstract

The fourth-generation QuantiFERON test for tuberculosis infection, QuantiFERON-TB Gold Plus (QFT-Plus) has replaced the earlier version, QuantiFERON-TB Gold In-Tube (QFT-GIT). A clinical need exists for information about agreement between QFT-Plus and other tests. We conducted this study to assess agreement of test results for QFT-Plus with those of QuantiFERON-TB Gold In-Tube (QFT-GIT), T-SPOT.TB (T-SPOT), and the tuberculin skin test (TST).

Funder

HHS | Centers for Disease Control and Prevention

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

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