Synonymous codon selection controls in vivo turnover and amount of mRNA in Escherichia coli bla and ompA genes-Reference-Cited by-同舟云学术

Synonymous codon selection controls in vivo turnover and amount of mRNA in Escherichia coli bla and ompA genes

Published:1996-05 Issue:9 Volume:178 Page:2718-2720
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Deana A¹,Ehrlich R¹,Reiss C¹

Affiliation:

1. Laboratoire Structure et Dynamique du Génome, Centre de Génétique Moléculaire, Centre National de la Recherch Scientifique, Gif sur Yvette, France.

Abstract

A number of silent codon changes were made in two Escherichia coli genes. For the ompA gene, the replacement of seven consecutive frequently used codons with synonymous infrequently used codons reduced the ompA mRNA level and its half-life. For the bla gene, the exchange of 24 codons for the most frequently used synonymous codons extended the bla mRNA half-life. A modification of ribosome traffic could account for these observations.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jb.178.9.2718-2720.1996

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