In Vitro Interactions of Echinocandins with Triazoles against Multidrug-Resistant Candida auris-Reference-Cited by-同舟云学术

In Vitro Interactions of Echinocandins with Triazoles against Multidrug-Resistant Candida auris

Published:2017-11 Issue:11 Volume:61 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Fakhim Hamed¹²,Chowdhary Anuradha³^ORCID,Prakash Anupam³,Vaezi Afsane⁴,Dannaoui Eric⁵^ORCID,Meis Jacques F.⁶⁷^ORCID,Badali Hamid⁸⁹^ORCID

Affiliation:

1. Department of Medical Parasitology and Mycology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran

2. Cellular and Molecular Research Center, Urmia University of Medical Sciences, Urmia, Iran

3. Department of Medical Mycology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India

4. Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran

5. Université Paris-Descartes, Faculté de Médecine, APHP, Hôpital Européen Georges Pompidou, Unité de Parasitologie-Mycologie, Service de Microbiologie, Paris, France

6. Department of Medical Microbiology and Infectious Diseases, Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands

7. Centre of Expertise in Mycology Radboudumc/CWZ, Nijmegen, The Netherlands

8. Department of Medical Mycology and Parasitology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

9. Pharmaceutical Sciences Research Center, Mazandaran University of Medical Sciences, Sari, Iran

Abstract

ABSTRACT We determined the in vitro interactions between echinocandins and azoles against 10 multidrug-resistant Candida auris strains by use of a microdilution checkerboard technique. Our results suggest synergistic interactions between micafungin and voriconazole with fractional inhibitory concentration index (FICI) values of 0.15 to 0.5, and we observed indifferent interactions when micafungin was combined with fluconazole (FICI, 0.62 to 1.5). Combinations of caspofungin with fluconazole or voriconazole exhibited indifferent interactions. No antagonism was observed for any combination.

Funder

Merck

Mazandaran University of Medical Sciences

Astellas Pharma US

European Society of Clinical Microbiology and Infectious Diseases

University of Delhi

Gilead Foundation

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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