Antibody-Based Inhibition of Pathogenic New World Hemorrhagic Fever Mammarenaviruses by Steric Occlusion of the Human Transferrin Receptor 1 Apical Domain-Reference-Cited by-同舟云学术

Antibody-Based Inhibition of Pathogenic New World Hemorrhagic Fever Mammarenaviruses by Steric Occlusion of the Human Transferrin Receptor 1 Apical Domain

Published:2021-08-10 Issue:17 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Ferrero Sol¹,Flores Maria D.²,Short Connor²,Vazquez Cecilia A.³⁴,Clark Lars E.⁵,Ziegenbein James²,Zink Samantha²,Fuentes Daniel²,Payes Cristian¹,Batto María V.¹,Collazo Michael⁶,García Cybele C.³⁴,Abraham Jonathan⁵⁷,Cordo Sandra M.³,Rodriguez Jose A.²,Helguera Gustavo¹^ORCID

Affiliation:

1. Laboratory of Pharmaceutical Biotechnology, Instituto de Biología y Medicina Experimental (IBYME-CONICET), Buenos Aires, Argentina

2. Department of Chemistry and Biochemistry, UCLA-DOE Institute for Genomics and Proteomics, University of California Los Angeles, Los Angeles, California, USA

3. Laboratorio de Virología, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires (UBA), IQUIBICEN, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)-UBA, Ciudad Universitaria, Buenos Aires, Argentina

4. IQUIBICEN, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)-UBA, Ciudad Universitaria, Buenos Aires, Argentina

5. Department of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, USA

6. Department of Biological Chemistry and Department of Chemistry and Biochemistry, University of California Los Angeles, Howard Hughes Medical Institute, UCLA-DOE Institute for Genomics and Proteomics, Los Angeles, California, USA

7. Department of Medicine, Division of Infectious Diseases, Brigham and Women’s Hospital, Boston, Massachusetts, USA

Abstract

Pathogenic clade B NWMs cause grave infectious diseases, the South American hemorrhagic fevers. Their etiological agents are Junin (JUNV), Guanarito (GTOV), Sabiá (SABV), Machupo (MACV), Chapare (CHAV), and a new Sabiá-like (SABV-L) virus recently identified in Brazil.

Funder

Consejo Nacional de Investigaciones Científicas y Técnicas

HHS | NIH | National Institute of General Medical Sciences

MINCyT | ANPCyT | Fondo para la Investigación Científica y Tecnológica

National Science Foundation

U.S. Department of Energy

HHS | NIH | Office of Research Infrastructure Programs, National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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