Effect of Passive Administration of Monoclonal Antibodies Recognizing Simian Immunodeficiency Virus (SIV) V2 in CH59-Like Coil/Helical or β-Sheet Conformations on Time of SIV mac251 Acquisition

Author:

Stamos James D.1ORCID,Rahman Mohammad Arif1ORCID,Gorini Giacomo1,Silva de Castro Isabela1ORCID,Becerra-Flores Manuel2,Van Wazer David J.3ORCID,N’Guessan Kombo F.45,Clark Natasha M.67,Bissa Massimiliano1ORCID,Gutowska Anna1ORCID,Mason Rosemarie D.8,Kim Jiae49,Rao Mangala9,Roederer Mario38,Paquin-Proulx Dominic45,Evans David T.67ORCID,Cicala Claudia10,Arthos James10,Kwong Peter D.3ORCID,Zhou Tongqing3ORCID,Cardozo Timothy2,Franchini Genoveffa1ORCID

Affiliation:

1. Animal Models and Retroviral Vaccines Section, Vaccine Branch, National Cancer Institute, Bethesda, Maryland, USA

2. New York University Grossman School of Medicine, NYU Langone Health, New York, New York, USA

3. Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA

4. Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, USA

5. Innate Immunology Laboratory, U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA

6. Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, USA

7. Department of Pathology and Laboratory Medicine, University of Wisconsin—Madison, Madison, Wisconsin, USA

8. ImmunoTechnology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA

9. Laboratory of Adjuvant and Antigen Research, U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA

10. Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA

Abstract

Studies suggest that the protection against SIV/simian-human immunodeficiency virus (SHIV) acquisition afforded by the SIV/HIV V1 deletion-containing envelope immunogens, delivered by the DNA/ALVAC vaccine platform, requires multiple innate and adaptive host responses. Anti-inflammatory macrophages and tolerogenic dendritic cells (DC-10), together with CD14 + efferocytes, are consistently found to correlate with a vaccine-induced decrease in the risk of SIV/SHIV acquisition.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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