The Human Adenovirus 2 Transcriptome: an Amazing Complexity of Alternatively Spliced mRNAs

Author:

Westergren Jakobsson Amanda12,Segerman Bo13,Wallerman Ola1,Bergström Lind Sara4,Zhao Hongxing2,Rubin Carl-Johan1,Pettersson Ulf2,Akusjärvi Göran1ORCID

Affiliation:

1. Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden

2. Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden

3. Department of Microbiology, National Veterinary Institute, Uppsala, Sweden

4. Department of Chemistry–BMC, Analytical Chemistry, Uppsala University, Uppsala, Sweden

Abstract

Work in the adenovirus system led to the groundbreaking discovery of RNA splicing and alternative RNA splicing in 1977. These mechanisms are essential in mammalian evolution, as they increase the coding capacity of a genome.

Funder

Swedish Foundation for Strategic Research

Cancerfonden

Kjell och Märta Beijers Stiftelse

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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