All Domains of SARS-CoV-2 nsp1 Determine Translational Shutoff and Cytotoxicity of the Protein-Reference-Cited by-同舟云学术

All Domains of SARS-CoV-2 nsp1 Determine Translational Shutoff and Cytotoxicity of the Protein

Published:2023-03-30 Issue:3 Volume:97 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Frolov Ilya¹^ORCID,Agback Tatiana²,Palchevska Oksana¹^ORCID,Dominguez Francisco¹,Lomzov Alexander²³,Agback Peter²,Frolova Elena I.¹^ORCID

Affiliation:

1. Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA

2. Department of Molecular Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden

3. Laboratory of Structural Biology, Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, Russia

Abstract

The nsp1 of SARS-CoV-2 is a multifunctional protein that modifies the intracellular environment for the needs of viral replication. It is responsible for the development of translational shutoff, and its expression alone is sufficient to cause a cytopathic effect (CPE).

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Swedish Foundation for Strategic Research

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.01865-22

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