Measles Virus Bearing Measles Inclusion Body Encephalitis-Derived Fusion Protein Is Pathogenic after Infection via the Respiratory Route-Reference-Cited by-同舟云学术

Measles Virus Bearing Measles Inclusion Body Encephalitis-Derived Fusion Protein Is Pathogenic after Infection via the Respiratory Route

Published:2019-04-15 Issue:8 Volume:93 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Mathieu Cyrille¹²³,Ferren Marion¹²³,Jurgens Eric¹²,Dumont Claire³,Rybkina Ksenia¹²,Harder Olivia⁴,Stelitano Debora¹²,Madeddu Silvia¹²⁵,Sanna Giuseppina¹²⁵,Schwartz Dayna¹²,Biswas Sudipta¹²,Hardie Diana⁶,Hashiguchi Takao⁷,Moscona Anne¹²⁸⁹,Horvat Branka³^ORCID,Niewiesk Stefan⁴,Porotto Matteo¹²¹⁰

Affiliation:

1. Center for Host-Pathogen Interaction, Columbia University Medical Center, New York, New York, USA

2. Department of Pediatrics, Columbia University Medical Center, New York, New York, USA

3. CIRI, International Center for Infectiology Research, Inserm, U1111, University Claude Bernard Lyon 1, CNRS, UMR5308, Ecole Normale Supérieure de Lyon, Lyon, France

4. Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA

5. Department of Biomedical Sciences, University of Cagliari, Cittadella Universitaria, Monserrato, Cagliari, Italy

6. Division of Medical Virology, Department of Clinical Laboratory Sciences, University of Cape Town and National Health Laboratory Service, Cape Town, South Africa

7. Department of Virology, Faculty of Medicine, Kyushu University, Fukuoka, Japan

8. Department of Microbiology and Immunology, Columbia University Medical Center, New York, New York, USA

9. Department of Physiology and Cellular Biophysics, Columbia University Medical Center, New York, New York, USA

10. Department of Experimental Medicine, University of Study of Campania Luigi Vanvitelli, Naples, Italy

Abstract

Measles virus (MeV) infection can be severe in immunocompromised individuals and lead to complications, including measles inclusion body encephalitis (MIBE). In some cases, MeV persistence and subacute sclerosing panencephalitis (SSPE) occur even in the face of an intact immune response. While they are relatively rare complications of MeV infection, MIBE and SSPE are lethal. This work addresses the hypothesis that despite a dysregulated viral fusion complex, central nervous system (CNS)-adapted measles virus can spread outside the CNS within an infected host.

Funder

HHS | National Institutes of Health

Agence Nationale de la Recherche

Japan Agency for Medical Research and Development

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01862-18

Reference65 articles.

1. Measles