The Small DdrR Protein Directly Interacts with the UmuDAb Regulator of the Mutagenic DNA Damage Response in Acinetobacter baumannii-Reference-Cited by-同舟云学术

The Small DdrR Protein Directly Interacts with the UmuDAb Regulator of the Mutagenic DNA Damage Response in Acinetobacter baumannii

Published:2022-03-15 Issue:3 Volume:204 Page:
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Pavlin Anja¹,Bajc Gregor¹,Fornelos Nadine²,Browning Douglas F.³⁴^ORCID,Butala Matej¹

Affiliation:

1. Department of Biology, Biotechnical Faculty, University of Ljubljana, Ljubljana, Slovenia

2. Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA

3. College of Health and Life Sciences, Aston University, Birmingham, UK

4. Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Birmingham, UK

Abstract

We previously identified a 50-residue bacteriophage protein, gp7, which interacts with and modulates the function of the LexA transcription factor from Bacillus thuringiensis . Here, we present data that indicates that the small DdrR protein from A. baumannii likely coordinates the SOS response and prophage processes by also interacting with LexA superfamily members.

Funder

Javna Agencija za Raziskovalno Dejavnost RS

UKRI | Biotechnology and Biological Sciences Research Council

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jb.00601-21

Reference28 articles.

1. Uncovering the mechanisms of Acinetobacter baumannii virulence

2. Essential Biological Processes of an Emerging Pathogen: DNA Replication, Transcription, and Cell Division in Acinetobacter spp