Recombinant ACE2 Expression Is Required for SARS-CoV-2 To Infect Primary Human Endothelial Cells and Induce Inflammatory and Procoagulative Responses-Reference-Cited by-同舟云学术

Recombinant ACE2 Expression Is Required for SARS-CoV-2 To Infect Primary Human Endothelial Cells and Induce Inflammatory and Procoagulative Responses

Published:2020-12-22 Issue:6 Volume:11 Page:
ISSN:2161-2129
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Nascimento Conde Jonas¹,Schutt William R.¹,Gorbunova Elena E.¹,Mackow Erich R.¹^ORCID

Affiliation:

1. Department of Microbiology and Immunology, Stony Brook University, Stony Brook, New York, USA

Abstract

SARS-CoV-2 infects pulmonary epithelial cells through ACE2 receptors and causes ARDS. COVID-19 causes progressive respiratory failure resulting from diffuse alveolar damage and systemic coagulopathy, thrombosis, and capillary inflammation that tie alveolar responses to EC dysfunction.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

G. Harold and Leila Y. Mathers Foundation

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.03185-20

Reference30 articles.

1. Pathology and Pathogenesis of SARS-CoV-2 Associated with Fatal Coronavirus Disease, United States

2. COVID-19: the vasculature unleashed