Carbon Catabolite Repression in Filamentous Fungi Is Regulated by Phosphorylation of the Transcription Factor CreA-Reference-Cited by-同舟云学术

Carbon Catabolite Repression in Filamentous Fungi Is Regulated by Phosphorylation of the Transcription Factor CreA

Published:2021-02-23 Issue:1 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

de Assis Leandro José¹,Silva Lilian Pereira²³,Bayram Ozgur⁴,Dowling Paul⁴,Kniemeyer Olaf⁵^ORCID,Krüger Thomas⁵,Brakhage Axel A.⁵^ORCID,Chen Yingying⁶,Dong Liguo⁶,Tan Kaeling⁶,Wong Koon Ho⁶,Ries Laure N. A.¹,Goldman Gustavo H.²³^ORCID

Affiliation:

1. University of Exeter, MRC Centre for Medical Mycology, Exeter, United Kingdom

2. Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirao Preto, Brazil

3. Institute for Advanced Study, Technical University of Munich, Garching, Germany

4. Biology Department, Maynooth University, Maynooth, Kildare, Ireland

5. Leibniz Institute for Natural Product Research and Infection Biology, Department of Molecular and Applied Microbiology, Institute of Microbiology, Friedrich Schiller University, Jena, Germany

6. Faculty of Health Science, University of Macau, Macau, China

Abstract

In filamentous fungi, the transcription factor CreA controls carbohydrate metabolism through the regulation of genes encoding enzymes required for the use of alternative carbon sources. In this work, phosphorylation sites were identified on Aspergillus nidulans CreA, and subsequently, the two newly identified sites S268 and T308, the previously identified but uncharacterized site S262, and the previously characterized site S319 were chosen to be mutated to nonphosphorylatable residues before their effect on CCR was characterized.

Funder

Technical University of Munich, Insitute for Advanced Study (TUMIAS), Germany

Deutsche Forschungsgemeinschaft

MCTI | Conselho Nacional de Desenvolvimento Científico e Tecnológico

Fundação de Amparo à Pesquisa do Estado de São Paulo

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.03146-20

Reference65 articles.