Affiliation:
1. College of Life Sciences, Nanjing Normal University, Nanjing, Jiangsu, China
Abstract
APOBEC3
(
A3
) genes have been thought to function in defense against retroviruses, whereas the evolutionary significance of A1 proteins in antiviral defense remains largely obscure. In this study, we identify the
A1
gene repertoire, characterize the A1-mediated mutation footprints in endogenous retroviruses (ERVs), and explore the evolutionary arms race between
A1
genes and ERVs across vertebrate species.
Funder
National Natural Science Foundation of China
Publisher
American Society for Microbiology
Subject
Virology,Insect Science,Immunology,Microbiology