IgG Responses to the Plasmodium falciparum Antigen VAR2CSA in Colombia Are Restricted to Pregnancy and Are Not Induced by Exposure to Plasmodium vivax-Reference-Cited by-同舟云学术

IgG Responses to the Plasmodium falciparum Antigen VAR2CSA in Colombia Are Restricted to Pregnancy and Are Not Induced by Exposure to Plasmodium vivax

Published:2018-08 Issue:8 Volume:86 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Lopez-Perez Mary¹,Larsen Mads Delbo¹²,Bayarri-Olmos Rafael²,Ampomah Paulina³,Stevenson Liz¹,Arévalo-Herrera Myriam⁴⁵,Herrera Sócrates⁴,Hviid Lars¹⁶^ORCID

Affiliation:

1. Centre for Medical Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

2. Laboratory of Molecular Medicine, Department of Clinical Immunology, Rigshospitalet, Copenhagen, Denmark

3. Department of Biomedical Sciences, School of Allied Health Sciences, University of Cape Coast, Cape Coast, Ghana

4. Caucaseco Scientific Research Center, Cali, Colombia

5. Faculty of Health, Universidad del Valle, Cali, Colombia

6. Centre for Medical Parasitology, Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark

Abstract

Clinical immunity to malaria is associated with the acquisition of IgG specific for members of the Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family of clonally variant antigens on the surface of infected erythrocytes (IEs). The VAR2CSA subtype of PfEMP1 mediates IE binding in the placenta.

Funder

Independent Research Fund Denmark

Colciencias

Consultative Committee for Development Research

Ghana Educational Trust Fund

Commission of the European Communities

Sven Andersen Research Foundation

Colombian Presidential Agency of International Cooperation

HHS | NIH | NIH Office of the Director

Novo Nordisk

Rigshospitalet

Publisher