Inhibition of poliovirus RNA synthesis by brefeldin A

Author:

Maynell L A1,Kirkegaard K1,Klymkowsky M W1

Affiliation:

1. Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder 80309-0347.

Abstract

Brefeldin A (BFA), a fungal metabolite that blocks transport of newly synthesized proteins from the endoplasmic reticulum, was found to inhibit poliovirus replication 10(5)- to 10(6)-fold. BFA does not inhibit entry of poliovirus into the cell or translation of viral RNA. Poliovirus RNA synthesis, however, is completely inhibited by BFA. A specific class of membranous vesicles, with which the poliovirus replication complex is physically associated, is known to proliferate in poliovirus-infected cells. BFA may inhibit poliovirus replication by preventing the formation of these vesicles.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Reference46 articles.

1. Ausubel F. M. R. Brent R. E. Kingston D. D. Moore J. G. Seidman J. A. Smith and K. Struhl. 1987. Current protocols in molecular biology. J. Wiley & Sons Inc. New York.

2. Poliovirus mutant that does not selectively inhibit host cell protein synthesis;Bernstein H. D.;Mol. Cell. Biol.,1985

3. Association of polioviral proteins of the P2 genomic region with the viral replication complex and virus-induced membrane synthesis as visualized by electron microscopic immunocytochemistry and autoradiography;Bienz K.;Virology,1987

4. Kinetics and location of poliovirus macromolecular synthesis in correlation to virus-induced cytopathology;Bienz K.;Virology,1980

5. Structural organization of poliovirus RNA replication is mediated by viral proteins of the P2 genomic region;Bienz K.;J. Virol.,1990

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