Affiliation:
1. Hôpital Universitaire Brugmann, Service de Biologie Clinique, 1020 Brussels, Belgium
Abstract
The killing rate of a zonal concentration gradient of penicillin G on
Staphylococcus aureus
was studied by using a previously described triple-layer technique, enzymatic inactivation of the antibiotic, and an automatic image analyzer. This gradient determines a target image, whose center is the reservoir of antibiotic (constituted by a paper disk containing 100 U of penicillin G) and whose successive concentric zones are: a zone of slow bactericidal activity (corresponding to high levels of penicillin G), a zone of maximal bactericidal activity (corresponding to optimal levels of penicillin G), and a zone of overgrowth situated in front of the antibiotic wave.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
8 articles.
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