Affiliation:
1. Department of Pathobiology, University of Washington School of Public Health and Community Medicine, Seattle, Washington 98105
Abstract
The complement-fixing activity of crude lipid extracts of 10
Mycoplasma
species was compared with that of whole organism antigens employing immune rabbit serum. Five species (
M. pneumoniae, M. neurolyticum, M. granularum, M. laidlawii
, and
M. fermentans
) showed serological activity, whereas the remaining five species (
M. canis, M. felis, M. gallisepticum, M. hyorhinis
, and
M. pulmonis
) did not show significant activity in their lipid fractions. The lipid fractions of the five species which had serological activity in their lipid fractions showed three groups of serological specificity.
M. pneumoniae
cross-reacted with
M. neurolyticum, M. granularum
cross-reacted with
M. laidlawii
, and
M. fermentans
showed specific activity. Acute and convalescent sera from human pneumonia patients from whom
M. pneumoniae
had been isolated showed antibody increases which could be measured nearly as well by lipids of
M. neurolyticum
as by those of
M. pneumoniae
. Only a few human convalescent sera showed antibody measureable by lipids of
M. granularum, M. pneumoniae
did not cross-react with
M. neurolyticum
by other serological parameters such as growth inhibition on agar or double immunodiffusion, indicating that only the lipid antigens of these two species cross-react.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Cited by
17 articles.
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