Affiliation:
1. Department of Veterinary Pathobiology, Texas A&M University, College Station 77843-4467.
Abstract
Monoclonal populations of feline T cells, derived from a specific-pathogen-free cat and expressing either the CD4 or CD8 surface antigen, were infected in vitro with two geographically distinct isolates of feline immunodeficiency virus (FIV). Both infected T-cell subsets exhibited decreased cell viability, expressed FIV-encoded proteins, and generated reverse transcriptase activity. All clones examined retained their original surface phenotype after infection. It appears, therefore, that both CD4+ and CD8+ T cells may be productively infected by FIV in vivo.
Publisher
American Society for Microbiology
Subject
Virology,Insect Science,Immunology,Microbiology
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