Inhibition of Human Immunodeficiency Virus Type 1 Replication prior to Reverse Transcription by Influenza Virus Stimulation

Author:

Pinto Ligia A.1,Blazevic Vesna1,Patterson Bruce K.2,Mac Trubey C.3,Dolan Matthew J.4,Shearer Gene M.1

Affiliation:

1. Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda,1 and

2. Laboratory of Viral Pathogenesis, Northwestern University Medical School, Chicago, Illinois2; and

3. Intramural Research Support Program, SAIC Frederick, NCI-FCRDC, Frederick,3 Maryland;

4. Wilford Hall Medical Center, Lackland AFB, Texas4

Abstract

ABSTRACT It is now recognized that, in addition to drug-mediated therapies against human immunodeficiency virus type 1 (HIV-1), the immune system can exert antiviral effects via CD8 + T-cell-generated anti-HIV factors. This study demonstrates that (i) supernatants from peripheral blood mononuclear cells (PBMC) stimulated with influenza A virus inhibit replication of CCR5- and CXCR4-tropic HIV-1 isolates prior to reverse transcription; (ii) the HIV-suppressive supernatants can be generated by CD4- or CD8-depleted PBMC; (iii) this anti-HIV activity is partially due to alpha interferon (IFN-α), but not to IFN-γ, IFN-β, the β-chemokines MIP-1α, MIP-1β, and RANTES, or interleukin-16; (iv) the anti-HIV activity is generated equally well by PBMC cultured with either infectious or UV-inactivated influenza A virus; and (v) the antiviral activity can be generated by influenza A-stimulated PBMC from HIV-infected individuals. These findings represent a novel mechanism for inhibition of HIV-1 replication that differs from the previously described CD8 anti-HIV factors (MIP-1α, MIP-1β, RANTES, and CD8 antiviral factor).

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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1. A separable temporal convolutional networks based deep learning technique for discovering antiviral medicines;Scientific Reports;2023-08-22

2. Deep-AVPpred: Artificial intelligence driven discovery of peptide drugs for viral infections;IEEE Journal of Biomedical and Health Informatics;2021

3. Type I Interferons: Distinct Biological Activities and Current Applications for Viral Infection;Cellular Physiology and Biochemistry;2018

4. References;HIV and the Pathogenesis of AIDS;2014-04-30

5. Approach to the Patient with HIV and Coinfecting Tropical Infectious Diseases;Tropical Infectious Diseases: Principles, Pathogens and Practice;2011

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