Evaluation of a Neonatal Rat Model for Prediction of Mumps Virus Neurovirulence in Humans-Reference-Cited by-同舟云学术

Evaluation of a Neonatal Rat Model for Prediction of Mumps Virus Neurovirulence in Humans

Published:2000-06 Issue:11 Volume:74 Page:5382-5384
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Rubin Steven A.¹,Pletnikov Mikhail²,Taffs Rolf¹,Snoy Phil J.¹,Kobasa Darwyn¹,Brown Earl G.³,Wright Kathryn E.³,Carbone Kathryn M.¹²⁴

Affiliation:

1. Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 208921;

2. Departments of Psychiatry2 and

3. Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada K1H 8M53

4. Medicine,4 The Johns Hopkins University, Baltimore, Maryland 21218; and

Abstract

ABSTRACT Neurovirulence of several mumps virus strains was assessed in a prototype rat neurovirulence test and compared to results obtained in the monkey neurovirulence test. The relative human neurovirulence of these strains was proportional to the severity of hydrocephalus in rats but not to lesion scores in the monkeys.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.74.11.5382-5384.2000

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