Quantitative Analysis of the Antiviral Activity of CD8 + T Cells from Human Immunodeficiency Virus-Positive Asymptomatic Patients with Different Rates of CD4 + T-Cell Decrease-Reference-Cited by-同舟云学术

Quantitative Analysis of the Antiviral Activity of CD8 + T Cells from Human Immunodeficiency Virus-Positive Asymptomatic Patients with Different Rates of CD4 + T-Cell Decrease

Published:2000-07-15 Issue:14 Volume:74 Page:6648-6651
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Salerno-Gonçalves Rosângela¹,Lu Wei¹,Andrieu Jean-Marie¹

Affiliation:

1. Laboratoire d'Oncologie et Virologie Moleculaire, Faculté Necker, Hôpital Laennec, 75340 Paris Cedex 07, France

Abstract

ABSTRACT We have measured in 22 asymptomatic human immunodeficiency virus type 1-infected patients (10 rapid progressors and 12 slow progressors) the proviral load of CD4 + T cells homogeneously superinfected by the same dose of a non-syncytium-inducing virus in the presence or in the absence of autologous CD8 + T cells. We demonstrated that the antiviral activity of CD8 + T cells was highly predictive of the rate of peripheral CD4 + T-cell decline.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.74.14.6648-6651.2000

Reference16 articles.

1. Phenotypic Analysis of Antigen-Specific T Lymphocytes

2. Gag-specific cytotoxic T lymphocytes from human immunodeficiency virus type 1-infected individuals: Gag epitopes are clustered in three regions of the p24gag protein

3. Deficient cellular immunity—finding and fixing the defects;Greenberg P. D.;Science,1999

4. Cytotoxic T lymphocytes in asymptomatic long-term nonprogressing HIV-1 infection. Breadth and specificity of the response and relation to in vivo viral quasispecies in a person with prolonged infection and low viral load;Harrer T.;J. Immunol.,1996

5. Kinetics of Gag-specific cytotoxic T lymphocyte responses during the clinical course of HIV-1 infection: a longitudinal analysis of rapid progressors and long-term asymptomatics;Klein M. R.;J. Exp. Med.,1995

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