A Catalytically Independent Function of Human DNA Polymerase Kappa Controls the Stability and Abundance of Checkpoint Kinase 1-Reference-Cited by-同舟云学术

A Catalytically Independent Function of Human DNA Polymerase Kappa Controls the Stability and Abundance of Checkpoint Kinase 1

Published:2021-10-26 Issue:11 Volume:41 Page:
ISSN:0270-7306
Container-title:Molecular and Cellular Biology
language:en
Short-container-title:Mol Cell Biol

Author:

Dall’Osto Marina¹,Pierini Laura²,Valery Nicolas¹,Hoffmann Jean-Sébastien³^ORCID,Pillaire Marie-Jeanne¹^ORCID

Affiliation:

1. Cancer Research Center of Toulouse, INSERM U1037, CNRS ERL5294, Université Paul Sabatier Toulouse III, Equipe labellisée Ligue Contre le Cancer, Laboratoire d’excellence Toulouse Cancer, Toulouse, France

2. AP-HP, DRCI Hôpital Saint-Louis, Paris, France

3. Laboratoire d’Excellence Toulouse Cancer (TOUCAN), Laboratoire de pathologie, Institut Universitaire du Cancer-Toulouse, Toulouse, France

Abstract

DNA polymerase kappa (Pol κ) has been well documented thus far for its specialized DNA synthesis activity during translesion replication, progression of replication forks through regions difficult to replicate, restart of stalled forks, and replication checkpoint efficiency. Pol κ is also required for the stabilization of stalled forks, although the mechanisms are poorly understood.

Funder

Region Languedoc Midi Pyrenees/INSERM fellowship

Agence Nationale de la Recherche

Institut National Du Cancer

Ligue Contre le Cancer

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MCB.00090-21

Reference62 articles.