Patient-to-Patient Transmission of Klebsiella pneumoniae Carbapenemase Variants with Reduced Ceftazidime-Avibactam Susceptibility-Reference-Cited by-同舟云学术

Patient-to-Patient Transmission of Klebsiella pneumoniae Carbapenemase Variants with Reduced Ceftazidime-Avibactam Susceptibility

Published:2019-10 Issue:10 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Munoz-Price L. Silvia¹,Reeme Allison E.²,Buchan Blake W.³^ORCID,Mettus Roberta T.⁴,Mustapha Mustapha M.⁴⁵,Van Tyne Daria⁴⁵,Shields Ryan K.⁴⁵,Doi Yohei⁴⁵⁶⁷

Affiliation:

1. Division of Infectious Diseases, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA

2. Department of Infection Prevention and Control, Froedtert Memorial Lutheran Hospital, Milwaukee, Wisconsin, USA

3. Department of Pathology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA

4. Division of Infectious Diseases, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA

5. Center for Innovative Antimicrobial Therapy, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA

6. Department of Microbiology, Fujita Health University, Toyoake, Japan

7. Department of Infectious Diseases, Fujita Health University, Toyoake, Japan

Abstract

We report patient-to-patient transmission of Enterobacter hormaechei isolates with reduced susceptibility to ceftazidime-avibactam due to production of KPC-40, a variant of KPC-3 with a two-amino-acid insertion in the Ω-loop region (L167_E168dup). The index patient had received a prolonged course of ceftazidime-avibactam therapy, whereas the second patient had not received the agent and still became colonized with the KPC-40-producing strain.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Eye Institute

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00955-19

Reference13 articles.

1. Microbiological features of KPC-producing Enterobacter isolates identified in a U.S. hospital system

2. Comprehensive Genome Analysis of Carbapenemase-Producing Enterobacter spp.: New Insights into Phylogeny, Population Structure, and Resistance Mechanisms