Utility of the Signal-to-Cutoff Ratio and Antigen Index from Fourth- and Fifth-Generation HIV-1/HIV-2 Antigen/Antibody Assays for the Diagnosis of Acute HIV Infection: Applicability for Real-Time Use for Immediate Initiation of Antiretroviral Therapy-Reference-Cited by-同舟云学术

Utility of the Signal-to-Cutoff Ratio and Antigen Index from Fourth- and Fifth-Generation HIV-1/HIV-2 Antigen/Antibody Assays for the Diagnosis of Acute HIV Infection: Applicability for Real-Time Use for Immediate Initiation of Antiretroviral Therapy

Published:2022-12-21 Issue:12 Volume:60 Page:
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Whitney Elena¹,Pitrak David¹,Beavis Kathleen G.²^ORCID,Moore Nicholas M.³⁴^ORCID,Shankaran Shivanjali⁴,Abeleda Ana Precy²,Schmitt Jessica¹,Sha Beverly E.⁴^ORCID

Affiliation:

1. University of Chicago Medicine, Department of Medicine, Section of Infectious Diseases and Global Health, Chicago, Illinois, USA

2. University of Chicago Medicine, Department of Pathology, Clinical Microbiology, Chicago, Illinois, USA

3. Rush University Medical Center, Department of Pathology, Chicago, Illinois, USA

4. Rush University Medical Center, Division of Infectious Diseases, Chicago, Illinois, USA

Abstract

Identification of individuals with acute HIV infection (AHI) and rapid initiation of antiretroviral therapy (ART) are priorities for HIV elimination efforts. Fourth- and fifth-generation HIV-1/HIV-2 antigen (Ag)/antibody (Ab) combination assays can quickly identify patients with AHI, but false-positive results can occur.

Funder

Chicago Department of Health with CDC

HHS | Health Resources and Services Administration

Gilead Sciences

CDPH and HHS

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/jcm.01204-22

Reference24 articles.