Double-Blind, Randomized, Placebo-Controlled Phase II Dose-Finding Study To Evaluate High-Dose Rifampin for Tuberculous Meningitis-Reference-Cited by-同舟云学术

Double-Blind, Randomized, Placebo-Controlled Phase II Dose-Finding Study To Evaluate High-Dose Rifampin for Tuberculous Meningitis

Published:2018-12 Issue:12 Volume:62 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Dian S.¹²³^ORCID,Yunivita V.⁴³,Ganiem A. R.²³,Pramaesya T.³,Chaidir L.⁵³,Wahyudi K.⁶,Achmad T. H.⁵,Colbers A.⁷,te Brake L.⁷,van Crevel R.¹,Ruslami R.⁴³,Aarnoutse R.⁷

Affiliation:

1. Department of Internal Medicine, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands

2. Department of Neurology, Faculty of Medicine, Universitas Padjadjaran Hasan Sadikin Hospital, Bandung, Indonesia

3. TB/HIV Research Centre, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia

4. Department of Pharmacology and Therapy, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia

5. Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia

6. Division of Epidemiology and Biostatistics, Department of Public Health, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia

7. Department of Pharmacy, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands

Abstract

High doses of rifampin may help patients with tuberculous meningitis (TBM) to survive. Pharmacokinetic pharmacodynamic evaluations suggested that rifampin doses higher than 13 mg/kg given intravenously or 20 mg/kg given orally (as previously studied) are warranted to maximize treatment response.

Funder

Radboud Universitair Medisch Centrum

Ministry of Education and Culture | Direktorat Jenderal Pendidikan Tinggi

National Academies of Sciences, Engineering, and Medicine | National Academy of Sciences

Kementerian Riset Teknologi Dan Pendidikan Tinggi Republik Indonesia

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01014-18

Reference31 articles.