In Vitro Activity and β-Lactamase Stability of Cefazaflur Compared with Those of β-Lactamase-Stable Cephalosporins

Abstract

The in vitro activity of cefazaflur, a parenteral cephalosporin, was determined against 590 clinical isolates. Cefazaflur inhibited the majority of gram-positive cocci at concentrations below 1 μg/ml except for enterococci. The agent was as active as cefamandole or cefoxitin against most Escherichia coli, Klebsiella pneumoniae , and Proteus mirabilis . Although it inhibited a number of strains of Enterobacter , indole-positive Proteus , and Serratia resistant to cephalothin, it was much less active against these organisms than were cefamandole or cefoxitin.