Affiliation:
1. Department of Microbiology, University of Colorado Medical Center, Denver, Colorado 80220
Abstract
Thymineless death of various ultraviolet (UV)-sensitive strains of
Escherichia coli
B and K-12 was investigated. It was found that
E. coli
B, B
s−12
, K-12
rec-21
, and possibly K-12 Lon
−
, all sensitive to UV, were also sensitive to thymine starvation. However, other UV-sensitive strains of
E. coli
were found to display the typical resistant-type kinetics of thymineless death. The correlation of these results with various other cellular processes suggested that the filament-forming ability of the bacteria might be involved in the mechanism of thymineless death. It was apparent from the present results that capacity for host-cell reactivation, recombination ability, thymine dimer excision, and probably induction of a defective prophage had little to do with determining sensitivity to thymine deprivation.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
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