Affiliation:
1. Division of Western Michigan, Bureau of Laboratories, Michigan Department of Public Health, Grand Rapids, Michigan 49503
Abstract
In a passive protection procedure in which the
ed
50
values of
Bordetella pertussis
antisera were determined, groups of mice were given graded intraperitoneal doses of serum, followed the next day by intracerebral challenge with 100,000 organisms. Antiserum produced with
B. pertussis
culture 5373, serotype 1.3, protected mice against challenge with culture 18-323, serotype 1.2.3, as effectively as did an antiserum produced with a serotype 1.2.3 culture. When two groups of mice similarly treated with pertussis immune serum were challenged with culture 353Z (serotype 1) and 18-323, respectively, much lower
ed
50
values were obtained with the animals challenged with 353Z. Passive protection tests with adsorbed antiserum gave equivocal results, suggesting that some of the adsorbing antigen remained in the serum and interfered with the tests. There was no evidence that serotype is related to protection.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Cited by
24 articles.
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